The most prescribed drug in every state of the U.S in 2021

July 2, 2021
5 min read

Medications are the only thing that is constant during the pandemic. In fact, people’s need for prescription-based medications has widely increased within the United States. To witness the frequency of the commonly prescribed drugs, you can go and visit your nearby pharmacists. 


However, if you have no time and are looking to save your hustle of going to the store, consider reading this article. I have listed the top most prescribed drugs in 2021. The report is based on the inter-state data collected from the past six months.


Further, this current list will tell you about the typical class of drugs that are commonly prescribed in the U.S. Reasons behind the primary prescription. Does it make a drug popular or not? And what are the most general health deficiencies diagnosed among Americans? Keep reading!

1. Lisinopril (Generic for Prinivil or Zestril)

lisinopril in the usa

Lisinopril is a prescription-based medication primarily recommended for patients after cardiovascular surgery. It has an angiotensin-converting enzyme inhibitor known for combating destructive issues after a heart attack. The person has more chances for survival after an intake of this drug.


It is also used for treating irregular blood pressure, heart stroke, and kidney failure triggered due to high sugar levels and blood pressure. Some evidence shows that due to stress in the covid-19, the number is increasing day-by-day. 


Nearly a large percent of the U.S. population is battling hypertension and is using lisinopril as it is generic for Prinivil and Zestril. You may get them at a lower cost, with an improved level of efficiency. 

2. Levothyroxine (generic for Synthroid)

It is a human-made edition of natural hormone used for overcoming hypothyroidism. The medication is known to bring hormone levels back on track for those with hormonal imbalance. 


The demographics of Arizona show a higher ratio of women than men. That’s why it is prominent to hit the most popular drug in Arizona. But, in Colorado, the percent of females does not exceed that of males. Still, it is mainly prescribed in the state. 

3. Azithromycin (generic for Zithromax, Z-PAK)

Azithromycin in the usa

Azithromycin is an antibiotic used for treating common ailments like throat, ear, and sinus infections. Other conditions like bronchitis, pneumonia and sexually transmitted disease are also cured using this drug.


SARS-COV-2 is a virus species that cause the spread of coronavirus. Azithromycin possesses properties of immunomodulatory and antiviral, which is considered to be significant as a first-line treatment to suppress the symptoms of the virus.

4. Metformin (generic for Glucophage)

Metformin in the usa

It is a type 2 diabetes drug, paired in combination with the proper diet and physical activity to help maintain the sugar levels in the blood. It is the generic version of Glucophage, making it entirely feasible and budget-friendly for U.S. residents. 

Also, it is considered the first-line treatment in New Mexico and Oklahoma as all other medications have shown no relevant results. 

5. Lipitor (atorvastatin)

Lipitor is a statin significantly used for treating high cholesterol. The molecules present is also known to prevent heart stroke, chest pain, and heart attack. In the decade previous then atorvastatin, the drug was the top-selling statin.


But now, since the generic version is out, people tend to buy atorvastatin due to its affordable range. However, it causes mild effects like diarrhea, constipation, fatigue, heartburn, head pain, and fatigue. Sometimes, it is also known to have muscle breakdown and spasms. 

6. Amlodipine (generic for Norvasc)

Amlodipine in the usa

High blood pressure is linked to several cardiovascular disabilities, leading to unforeseen circumstances when kept untreated for a while. Therefore, doctors prescribe medication like Amlodipine that maintains blood pressure. It is efficiently used in treating chest pain that often triggers the rise in blood pressure count. 

7. Amoxicillin

Amoxicillin in the usa

Pain in your ear, nose, and throat are the signs of bacterial infection. It acts as solid support for respiratory depression and other illnesses. The best part is, this pill is suitable for kids too. Most of them are aware that antibiotics are mainly given to children, as all the viruses and infections attack them. California has a lot of bacterial cases cured using Amoxicillin. 

8. Hydrochlorothiazide

Hydrochlorothiazide in the usa

Hydrochlorothiazide is a medication used to help you pass enough urine so that no other extra fluids stay back in your urinary glands. It also eventually helps in excreting extra fluid-like salt and water in your body. Other fluids stored in your system after critical conditions like hepatic impairment, heart failure, or kidney disease can be exited strategically using Hydrochlorothiazide. The demographics show that a large percentage of California and Carolina is prescribed this medication. 

9. Albuterol (Accuneb, Ventolin, Proair, Proventil)

Albuterol in the usa

The muscle clot in the lungs leads to irregular breathing. Albuterol is one such medication used to relax the discomforting muscle contraction, leading to asthma prevention. Many physicians from Virginia and North California recommend Albuterol due to its potent mechanism and lesser side effects when used ethically. 

10. Gabapentin (Neurontin)

Gabapentin in the usa

A recent study shows that adults in the U.S. suffer from stress and hypertension, leading to the occurrence of seizures. The number of epilepsy syndrome is increasing day by day, for which doctors use Gabapentin. This drug is known to relax nerve pain by pausing the chemical interaction leading to lesser episodes of seizures. 

Take away

The list of medications is only applicable to U.S. residents. The rest of the nations may have different medications belonging to various classes of drugs, and also, depending upon the demographics and the disorder rate, the popularity of the medications changes. This article is delicately written from the best information gathered from leading pharmacies. As per the significant sales rate, we outlined the most popular drugs in the United States during the pandemic.


Prices of the 20 most commonly prescribed drugs in the US increased. Pharmacoecon. Outcomes News 26, 16 (1995).

Anon, Prescribed and Over-the-Counter (OTC) Drugs. Key Concepts in Drugs and Society, pp.88–91. Available at:

Anon, Commonly prescribed drugs. Geriatric Medicine for Old Age Psychiatrists, pp.215–246. Available at:

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