Complete Guide Naproxen And Paracetamol Together

July 27, 2021
5 min read

Introducing acetaminophen and naproxen work in different ways to control pain, with some overlapping side effects. It is essential to understand how each drug works to manage your pain.

In 2018 ( 2019), naproxen was prescribed more than 7 million times, making it one of the most commonly prescribed drugs in the UK. This short article explains the reasons for its use in treating pain and inflammation and the answers to whether it and Paracetamol should be taken together. These tips will help you get an introduction to Paracetamol, naproxen, warnings, and other information you should know.

In the current opioid crisis26, using the smallest possible amount of opioids is critical. 27 Combining Paracetamol (1000 mg) with ibuprofen (400 mg) did not result in lower morphine use but did result in lower resting pain (24 hours) and lower nausea risk (24 hours). A recent network meta-analysis of non-opioid analgesics for major surgery28 demonstrated similar results in terms of morphine-saving effects in studies, but this included few studies with direct comparisons between the combination of Paracetamol and NSAIDs and Paracetamol and NSAIDs. A third of the patients completed a two-year randomized, double-blind trial of Paracetamol (2,600 mg/day) and naproxen (750 mg/day) after two years. The only outcome favoring the latter was an improvement in walking time of 50 feet.

What are Naproxen and Paracetamol used for?

Naproxen is sold under the brand name Aleve. It belongs to the group of medications called non-steroidal anti-inflammatory antidotes. The drug naproxen is available on prescription but also over-the-counter. This medication is used to treat pain, menstrual cramp, illnesses such as gout and fever. On the other hand, Paracetamol, also known as acetaminophen, is a medication used to cure fever and mild to moderate pain. 

Drug Interactions between naproxen and Paracetamol

There is a total number of 389 drugs that are known to interact with naproxen 

70 major

301 moderate

18 minors. 

Some of the drugs are- 

  • Adderall 
  • Aspirin Low Strength 
  • Benadryl 
  • Cymbalta 
  • Fish Oil 
  • Flexeril 
  • Lexapro 
  • Lyrica 

There is a total number of 116 drugs that are known to interact with Paracetamol 

8 major

73 moderate

35 minor interactions. 

Some of the drugs are- 

  • amitriptyline
  • amlodipine
  • aspirin
  • atorvastatin
  • bisoprolol
  • ceftriaxone
  • codeine
  • diazepam

Can you take naproxen and Paracetamol together?

Do not take this medication with ibuprofen or other NSAIDs. Since both drugs have the same effect, it is an overdose to take more than one drug during a dosing period. You cannot adjust your dose of both medications by taking them at different times when you are taking them. For example, if you take one dose of naproxen, you can’t take another dose for eight hours. This means that if you take a naproxen dose as instructed by the dosing instructions, take it within 6-8 hours and should not take any other NSAIDs or painkillers during this period. This is because sodium is heavily degraded, meaning that its sodium remains active for much longer than other anti-inflammatory drugs.  

What are other pain relievers compatible with naproxen?

Naproxen is used as a remedy to cure the pain in joints and muscles. 

The other pain relievers that can be used with this medication are-

  • Paracetamol with naproxen. 
  • One can also consume opioid-type pain relievers such as codeine, co-codamol, tramadol, or morphine with naproxen. 

What should you avoid if you're taking naproxen?

It could be dangerous for you if you don’t take proper precautions.

Before the consumption of naproxen, you should take care of the following things-

  • Avoid this treatment during the third trimester of a pregnant woman.
  • Breastfeeding must be avoided during this medication.
  • Be cautious if you are taking naproxen and are more than 65-year-old. 
  • Kids younger than 2 years old should not be exposed to naproxen. 
  • Avoid over-dosing and follow your physician’s instructions.
  • Avoid many cold and flu remedies and over-the-counter painkillers with ibuprofen or aspirin if you are also taking naproxen.

Also take a note

  • Slow-release, extended-release, or enteric-coated medicines should be swallowed whole, not crushed or chewed.
  • Do not use this medication in the setting of heart bypass surgery.
  • Adults between 12 and 65 should take every 12 hours a tablet of 220 mg naproxen for mild to moderate pain and fever or mild to moderate pain.
  • Children 12 years and older should not take the drug unless their doctor recommends it. 

Naproxen may contain inactive ingredients that can cause allergic reactions or other problems. Tell your doctor or pharmacist before taking naproxen if you are allergic to naproxen (aspirin, aspirin, or other NSAIDs such as ibuprofen or Zelecoxib) or if you have other allergies before taking it. Be sure to check the ingredients of different medications before taking them with naproxen and ask your pharmacist for advice. 


Emanuela Ricciotti, PhD and Garret A. FitzGerald (2011). Prostaglandins and Inflammation. Available at:  Accessed on 21/07/2021
Courtney PDoherty M
Key questions concerning paracetamol and NSAIDs for osteoarthritis
. Accessed on 21/07/2021
Seideman P. Additive effect of combined naproxen and paracetamol in rheumatoid arthritis. Br J Rheumatol. 1993 Dec;32(12):1077-82. doi: 10.1093/rheumatology/32.12.1077. PMID: 8252318. Accessed on 21/07/2021

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