Strongest Skin Numbing Creams Available Over The Counter In 2021

July 29, 2021
6 min read

Numbing creams are a beneficial remedy to have on hand in your bathroom cabinet when you have muscle soreness, joint pain, or wounds. While choosing a numbing cream, it’s essential to note what you will be using it for to purchase a cream that’s best suited to those needs. The Cream comes with some of the hazardous side effects, too, if not used correctly. 

What are the main active ingredients in skin-numbing creams?

Numbing creams are admired with people who suffer from utmost pain, such as those who take part in major sports, or with people who have in progress pain-linked problems like arthritis or chronic back pain. They’re also often purchased by people who get tattoos or laser therapy.

  • The active materials are lidocaine and prilocaine. 
  • Each gram includes 25 mg of lidocaine and 25 mg of prilocaine.
  • Other components of the Cream are macrogol glycerol hydroxy stearate, Carbomer 974P, sodium hydroxide, and purified water.

What skin numbing creams are available at the pharmacy?

Skin numbing creams are an effective way to facilitate medical and cosmetic procedures. Dermatologists in particular find these creams useful in a variety of situations they are confronted with on a daily basis. These creams are available in various qualities and are available over-the-counter or on prescription from your doctor.

UltraNumb Topical Anesthetic Cream

UltraNumb Topical Anesthetic Cream

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Ebel Numbing 5% Lidocaine

Ebel Numbing 5% Lidocaine

Ebel is used for temporary relief and anorectal pain linked with anorectal discomfort or inflammation. The numbing effect of Ebanel Numb 520 will take place within 2-3 minutes after applying the Cream to the area. The maximal effect will be obtained within 20 minutes.

Aspercreme Pain Relieving Cream

Aspercreme Pain Relieving Cream

Aspercreme is clinically proven for major arthritis, joint & muscle pain. This is used to cure Arthritis, Backache, Muscle Strains, Sprains, and Bruises. This Cream is for adults and children who are over 12 years. It absorbs in the skin when massaged on the painful area. It is a temporarily main reliever cream.

Things to remember:

  • Keep the medication away from children. 
  • If pregnant or breastfeeding, then it is recommended to ask your physician before using. 

LMX4 numbing Cream

LMX4 numbing Cream

This Cream is designed to provide an effective numbing for people who undergo laser treatments and injections. It helps to reduce up to 75% of the pain experienced by the patients from laser treatments, skin surgeries, tattoo removal, and sunburn from outer tanning lotions. The Cream is also used to treat and cure minor skin irritations and can be applied four times a day, removing pain from cuts. 

The key features of this Cream are:

  • Treatment for tattoo removal, injections, and laser treatments.
  • Contains 4% of lidocaine.
  • A person can use this Cream up to 4 times a day.
  • Cure skin irritations and swelling. 

Biofreeze Professional Pain-Relieving Gel

Biofreeze Professional Pain-Relieving Gel

This is an excellent product for massaging onto muscle areas such as the joints and back. It is free from addictive and control substances, so it is excellent for people looking for natural and skin-friendly products to cure the discomfort of joints and muscles. The gel has a cooling impact that provides long-lasting therapy and is a topical analgesic that professionals such as chiropractors trust to help with joint pain in their patients.

Key features of this Cream are:

  • Includes a blend of herbs.
  • Useful therapy for backaches, arthritis, and sore muscles
  • It is free from parabens, salicylates, and addictive materials.

Advanced Numb 5% Lidocaine Pain Relief Cream

Advanced Numb 5% Lidocaine Pain Relief Cream

This is another effective cream. It works within 20-25 minutes after application and keeps the numbness for 2 hours. It is non-oily and helps reduce inflammation. It is enriched with vitamin E and helps relieve painful swelling also aids in moisturizing the skin to prevent itchiness

Emla numbing Cream

Emla numbing Cream

Emla numbing Cream is the most popular Cream requested by people and also prescribed by the GPs. This Cream is licensed for newborn infants 0-2 months and all the other age groups of children’s and adult age groups. 

How and when to apply:

  • It is recommended to apply Emla cream at least an hour before the insertion of a needle.
  • Kindly check the product information on the leaflet for applications before other procedures.
  • Half of the tube is applied to the area. Emla should not be rubbed in.
  • Adhesive Tegaderm dressing must be applied to the area.
  • The dressing should be left for at least an hour.
    After one hour (and a maximum of 5 hours, depending on the age), the dressing should be taken out, and the area cleaned with alcohol before the procedure.

Daniela cream

Daniela cream

Daniela cream contains the same active ingredients as Lidocaine and Prilocaine as Emla. This Cream works by stopping pain by acting on peripheral nerves, preventing the pain during surgery.

What are the side effects of skin-numbing creams?

Visit your doctor if you have:

  • critical burning or irritation
  • swelling or redness
  • sudden drowsiness 
  • blurred vision, ringing in your ears
  • abnormal sensations of temperature.
  • mental/mood changes
  • fainting
  • slow or shallow breathing
  • bluish skin around the mouth

Common side effects- light irritation or burning, insensibility in places where the medicine is accidentally applied, changes in skin color, itching, or rash. 

Get emergency medical help if you have allergic reactions like- hives, difficulty breathing, swelling of your face, lips, tongue, or throat. 

Where to buy skin-numbing cream?

For local numbing and pain management, doctors typically use local anesthetics sanction by the U.S. Food and Drug Administration. Many of these are also accessible in over-the-counter strength for home use.


The US Food and Drug Administration (FDA) warned consumers on February 6 that skin creams can cause life-threatening side effects such as irregular heartbeats, seizures, and even death. The FDA has warned of potentially serious and life-threatening side effects from improper use of local anesthetics and skin-numbing products available over-the-counter. The authority urged people who use these products to consult their doctor first about the correct application.

In 2006, FDA advised five pharmacies not to discontinue standardized versions of topical anesthesia creams available for general sale. Concerns grew about the presence of high concentrations of compound anesthetic mixtures in these creams. These products also lacked appropriate warnings and instructions for use.


Anesthetic cream J-Caine (Lidocaine 10.56%) is the strongest. 

Best numbing creams for tattoos are: 

  • Zensa Topical Anesthetic Numbing Cream 
  • Uber Numb Topical Numbing Cream 
  • TKTX Numbing Cream 
  • Deeveeant Topical Numbing Cream  

The best creams for waxing are Numb Master Topical Anesthetic Cream, Lidocaine Plus Maximum Strength, No Scream Cream Relax and Wax, and many more. 


Alster Tina (2013). Review of Lidocaine/Tetracaine Cream as a Topical Anesthetic for Dermatologic Laser Procedures. Available at: Accessed on 23/07/2021
eMC (2019). SmPC: Emla cream. Available at: Accessed on 23/07/2021
Eidelman Anthony (2005).  Topical Anesthetics for Dermal Instrumentation: A Systematic Review of Randomized, Controlled Trials. Annals of Emergency Medicine, Volume 46, Issue 4, 343 – 351 Available at: Accessed on 23/07/2021

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